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The viral replication of HIV-1 depends on cellular co-factors and cellular pathway. Host cell proteins that particularly assist the viral integration have been determined and termed as integration cofactors (INCFs). The lens epithelium-derived growth factor (LEDGF/p75) is the first identified and the best characterized one to date. The interface of protein-protein interaction between LEDGF/p75 and HIV IN is primarily formed by HIV IN binding domain (LEDGF/p75 IBD) in the C-terminal region of LEDGF/p75 with the HIV IN catalytic core domain (IN CCD). Dexlansoprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus.