Analysis Biomolecular Interactions of TREM2 with HDL by BLI (CAT#: STEM-MB-0238-CJ)

Introduction

Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. In addition, TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather than as a consequence of the disease. And HDL (high-density lipoprotein) cholesterol, sometimes called “good” cholesterol, can absorb cholesterol in the blood and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke.