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RHA0385 can recognize other influenza A viral strains in spite of low sequence homology. This attribute can be used to create RHA0385-based aptasensors for influenza A viruses. The proposed structure of RHA0385 is a parallel G-quadruplex composed of three G-tetrads featuring three propeller loops; one loop is 7 nucleotides long (a major loop), whereas the other two are each a single nucleotide in length (minor loops).