Analysis of ABL1 Gene Rearrangement by Southern Blot Technology (CAT#: STEM-MHT-0053-LGZ)

Introduction

Official Full Name: ABL proto-oncogene 1, non-receptor tyrosine kinase
Also known as: ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
This gene is a proto-oncogene that encodes a tyrosine kinase protein involved in a variety of cellular processes including cell division, adhesion, differentiation and stress response. The activity of this protein is negatively regulated by its SH3 domain, thus, deletion of the region encoding this domain results in the generation of an oncogene. This ubiquitously expressed protein has DNA-binding activity regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. In various leukemias, this gene has been found fused to a variety of translocation partner genes, most notably the t(9;22) translocation, resulting in a fusion to the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants containing an alternative first exon spliced to the remaining common exon.