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Official Full Name: acetyl-CoA carboxylase alpha
Also known as: ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two forms of ACC, alpha and beta, encoded by two different genes. ACC-α is highly enriched in adipogenesis tissues. The enzyme is controlled long-term at the transcriptional and translational levels and regulated in the short-term by phosphorylation/dephosphorylation of targeted serine residues and allosteric conversion of citrate or palmitoyl-CoA. Multiple different alternatively spliced transcript variants were found in the 5' sequence of this gene, encoding different isoforms.