Analysis of ADAM15 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0774-LGZ)

Introduction

Official Full Name: ADAM metallopeptidase domain 15<br />Also known as: MDC15<br />The protein encoded by this gene is a member of the ADAM (disintegrin and metalloprotease) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. The protein contains multiple functional domains, including a zinc-binding metalloprotease domain, a disintegrant-like domain, and an egf-like domain. Through its disintegrant-like domain, this protein specifically interacts with the integrin chain β3. It also interacts with Src family protein tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may play a role in cell-cell adhesion as well as cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been observed.