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Official Full Name: Rho/Rac guanine nucleotide exchange factor 2
Also known as: GEF; Lfc; P40; GEFH1; LFP40; GEF-H1; NEDMHM
Rho GTPases play an important role in many cellular processes initiated by extracellular stimuli through G protein-coupled receptors. The encoded protein can form complexes with G proteins and stimulate rho-dependent signaling. Alternative splicing transcript variants encoding different isoforms have been identified