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Official Full Name: ATPase Na+/K+ transporting subunit beta 1
Also known as: ATP1B
The protein encoded by this gene belongs to the Na+/K+ and H+/K+ atpase β-catenin family, and belongs to the Na+/K+-atpase subfamily. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradient of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various organic and inorganic molecules, and electrical excitability in nerves and muscles. The enzyme is composed of two subunits, a larger catalytic subunit (α) and a smaller glycoprotein subunit (β). The β subunit regulates the number of sodium pumps delivered to the plasma membrane through the assembly of α/β heterodimers. The glycoprotein subunit of the Na+/K+-atpase is encoded by multiple genes. This gene encodes the β1 subunit. Alternative splicing transcript variants encoding different isoforms have been described, but their biological validity is unclear.