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Official Full Name: ATPase plasma membrane Ca2+ transporting 4
Also known as: MXRA1; PMCA4; ATP2B2; PMCA4b; PMCA4x
The protein encoded by this gene belongs to the P-type primary ion transporting ATPase family, which is characterized by the formation of an aspartate phosphate intermediate in the reaction cycle. These enzymes remove divalent calcium ions from eukaryotic cells in very large concentration gradients and play a key role in intracellular calcium homeostasis. Mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes, and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different alloforms and splice variants is regulated in a developmental, tissue and cell type specific manner, suggesting that these pumps are functionally adapted to the physiological demands of specific cells and tissues. This gene encodes plasma membrane calcium ATPase isoform 4. Alternative splicing transcript variants encoding different isoforms have been identified.