Analysis of BAG4 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1892-LGZ)

Introduction

Official Full Name: BAG cochaperone 4<br />Also known as: SODD; BAG-4<br />The protein encoded by this gene is a member of the bag1-related protein family. BAG1 is an anti-apoptotic protein that functions by interacting with a variety of apoptosis and growth-related proteins, including BCL-2, raf protein kinase, steroid hormone receptors, growth factor receptors, and heat shock protein 70kda family members . The protein contains a BAG domain near the C-terminus, which can bind and inhibit the chaperone activity of Hsc70/Hsp70. The protein was found to associate with the death domains of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor 3 (DR3), thereby negatively regulating downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells, which undergo apoptosis when integrin-mediated matrix contacts are lost. Alternative splicing transcript variants encoding different isoforms have been identified.