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Bcl-2 gene (namely B-cell lymphoma/leukemia-2 gene) is an oncogene, which can obviously inhibit cell apoptosis, and some studies in recent years have begun to reveal the mechanism of this effect. Bcl-2 is the main target molecule in the study of apoptosis molecular mechanism. With the deepening of the research on Bcl-2 and apoptosis itself, the mechanism of action of Bcl-2 and the molecular mechanism of apoptosis are finally elucidated, thereby improving the understanding, diagnosis and treatment of diseases related to apoptosis.