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Official Full Name: BRCA2 DNA repair associated<br />Also known as: FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2<br />Inherited mutations in the BRCA1 and BRCA2 genes increase the lifetime risk of breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in the maintenance of genome stability, especially the homologous recombination pathway of double-strand DNA repair. The largest exon of these two genes is exon 11, which contains the most important and most common mutations in breast cancer patients. The BRCA2 gene is located on human chromosome 13q12.3. The BRCA2 protein contains several copies of a 70 aa motif, called the BRC motif, that mediate binding to the RAD51 recombinase, which functions in DNA repair. BRCA2 is considered a tumor suppressor gene because tumors with BRCA2 mutations often exhibit loss of heterozygosity (LOH) for the wild-type allele.