Analysis of Caspase-1 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0076-LGZ)

Introduction

Caspase is a family of proteases involved in the process of apoptosis, including more than 10 members. Caspase-1 is the only caspase that cleaves IL-1b and IL-18 precursors to produce active cytokines. Caspase-1 regulates apoptosis by cleaving Bcl-XL, and regulates related cytokine-mediated immune-inflammatory responses by cleaving cytokine precursors.

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Principle Applications Procedure Materials Notes Related Products

Principle

MSD electrochemiluminescence technology is mainly based on ultra-sensitive multi-factor electrochemiluminescence analyzer MES0 Sector600 or Quickplex SQ120. Through dot matrix technology, the detection of 10 indicators per well can be realized in the 96-hole graphite electrode plate. It can also be customized to realize the screening detection of 100 index wells in a 24-well plate.

Applications

Cytokines & Chemokines, Immunology/Inflammation

Procedure

1. Coat the capture antibody on the well plate.
2. Add samples/calibrators.
3. Add detection antibody.
4. Read the plate and analyze the data.

Materials

• Sample Type: Serum, Plasma

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