Analysis of Caspase-3 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0077-LGZ)

Introduction

Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a key performer of apoptosis because it is partially or fully responsible for proteolytic cleavage of many key proteins, such as ribozyme poly (ADP-ribose) polymerase (PARP). Activation of Caspase-3 requires proteolysis of its inactive proenzyme form into activated p17 and p12 fragments. Caspase-3 cleavage requires aspartate residues located at P1.