Analysis of CD30/TNFRSF8 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0087-LGZ)

Introduction

Leukocyte antigen cluster of differentiation 30 (CD30), also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8), is a membrane protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. The CD30 protein is expressed by activated but not resting T cells and B cells. CD30 may play a role in the regulation of cell growth and transformation of activated lymphoblastic cells, and may also play an important role in human immunodeficiency virus replication. TRAF2 and TRAF5 can interact with this receptor and mediate signal transduction leading to NF-κB activation. As a positive regulator of apoptosis, the CD30 protein can induce cell death or proliferation depending on the cell type and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body from autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, and CD30 is also associated with leukocytes in patients with chronic inflammatory diseases such as lupus, asthma, and rheumatoid arthritis.