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Official Full Name: CD46 molecule
Also known as: MCP; TLX; AHUS2; MIC10; TRA2.10
The protein encoded by this gene is a type I membrane protein that is a regulatory part of the complement system. The encoded protein has cofactor activity and can inactivate complement components C3b and C4b through serum factor I, thereby protecting host cells from complement damage. In addition, the encoded protein acts as a receptor for measles virus Edmonston strain, human herpesvirus-6, and pathogenic Neisseria type IV pili. Finally, the protein encoded by this gene may be involved in the fusion of sperm and oocyte during fertilization. Mutations at this site are associated with susceptibility to hemolytic uremia. Alternately spliced transcript variants encoding different isoforms have been described.