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Official Full Name: centromere protein S
Also known as: MHF1; APITD1; CENP-S; FAAP16
The gene is located in a neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain similar to that found in the TATA box-binding protein-associated factor TAF(II)31, which is required for p53-mediated transcriptional activation. The gene is expressed at very low levels in neuroblastoma tumors and has been shown to reduce cell growth in neuroblastoma cells, suggesting that it may play a role in the cell death pathway. This protein is part of several complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (distal nucleosome) complex. Known functions include participation in chromatin binding of the FA core complex and a role in the stable assembly of the outer centromere. Alternative splicing of this gene results in multiple transcript variants. There is also a native readable transcript between this gene and the downstream cortistatin (CORT) gene. A pseudogene associated with apitd1 was found on chromosome 7.