Analysis of Chromogranin-A (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0105-LGZ)

Introduction

Chromogranin A (chromograninA, CGA) is a 48 kD acidic, hydrophilic secreted protein located in the chromaffin granules of neuroendocrine cells. CGA belongs to the chromaffin protein family and is present in catechol-secreting vesicles in all neuroendocrine cells, and was originally found in the secretory granules of adrenal chromaffin cells. In the chromaffin granules of the adrenal medulla, it is co-secreted with catecholamines and calcium. The protein is found in sympathetic nerve endings and myocardium, pancreas, central and peripheral nervous systems, intestinal endocrine tissues, thyroid and parathyroid glands and other tissues. Its proteolysis is tissue-specific, and the difference in the location of the break is related to the tissue in which it is located.