Analysis of CNOT7 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1921-LGZ)

Introduction

Official Full Name: CCR4-NOT transcription complex subunit 7<br />Also known as: CAF1; CAF-1; Caf1a; hCAF-1<br />The protein encoded by this gene binds to an anti-proliferation protein B-cell translocation protein 1, and negatively regulates cell proliferation. The association of these two proteins is driven by the phosphorylation of anti-proliferative proteins, causing signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contacts. The encoded protein downregulates the innate immune response, thus providing a therapeutic target to enhance its antimicrobial activity against foreign pathogens. Alternative splicing of this gene results in multiple transcript variants. Associated pseudogenes were found on chromosomes 1 and X.