Analysis of CRTC2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0890-LGZ)

Introduction

Official Full Name: CREB regulated transcription coactivator 2<br />Also known as: TORC2; TORC-2<br />This gene encodes a transducer member of the transcriptional coactivator family that regulates cAMP response element binding protein activity. These proteins promote the transcription of genes targeted by cAMP response element binding proteins and thus play an important role in many cellular processes. Under basal conditions, the encoded protein is phosphorylated by AMP-activated protein kinase or salt-inducible kinase and sequestered in the cytoplasm. Upon activation by cAMP or elevated calcium, the encoded protein translocates to the nucleus and increases the expression of target genes. A single nucleotide polymorphism in this gene may increase the risk of developing type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.