Analysis of CXCL1/KC by ELISA (CAT#: STEM-MB-1529-LGZ)

Introduction

Chemokine (C-X-C motifs) ligand 1(CXCL1) is a small molecular weight cytokine belonging to the CXC chemokine family, formerly known as GRO1 oncogene, GROα, KC, and neutrophil activating Protein 3 (NAP-3). In humans, the protein is encoded by the CXCL1 gene. CXCL1, secreted by human melanoma cells, has mitogenic properties and is related to the pathogenesis of melanoma. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil-chemotactic activity. The chemokine produces a signal through the chemokine receptor CXCR2, which triggers its effect. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors. It is involved in blood vessel growth, inflammation, wound healing and tumorigenesis. Preliminary studies in mice have shown that CXCL1 reduces the severity of multiple sclerosis and can provide neuroprotective effects.