Analysis of DEDD Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0907-LGZ)

Introduction

Official Full Name: death effector domain containing<br />Also known as: DEFT; KE05; DEDD1; FLDED1; DEDPro1; FLDED-1; CASP8IP1<br />This gene encodes a protein that contains a death effector domain (DED). DED is a protein-interaction domain shared by adaptors, regulators, and executors of the programmed cell death pathway. Overexpression of this gene induces weak apoptosis. Upon stimulation, the protein was found to translocate from the cytoplasm to the nucleus and co-localize with UBTF, an essential factor required for RNA polymerase I transcription in the nucleus. This gene has at least three transcript variants encoding the same protein.