Analysis of DUSP10 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0910-LGZ)

Introduction

Official Full Name: dual specificity phosphatase 10<br />Also known as: MKP5; MKP-5<br />Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants.