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Official Full Name: dual specificity phosphatase 8
Also known as: HB5; HVH8; HVH-5; C11orf81
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are involved in cell proliferation and differentiation. Different members of the dual-specificity phosphatase family exhibit different substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different patterns of induction of their expression by extracellular stimuli. The gene product inactivates SAPK/JNK and p38, is mainly expressed in adult brain, heart and skeletal muscle, localizes in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless DUSP8 pseudogene is present on chromosome 10q11.2.