Analysis of EIF4G2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2399-LGZ)

Introduction

Official Full Name: eukaryotic translation initiation factor 4 gamma 2
Also known as: P97; AAG1; DAP5; NAT1
Translation initiation is mediated by cap-specific recognition by eukaryotic translation initiation factor 4F (eIF4F), a cap-binding protein complex consisting of three subunits: eIF4A, eIF4E, and eIF4G. The protein encoded by this gene has similarity to the c-terminal region of eIF4G, which contains the binding sites of eIF4A and eIF3; in addition, eIF4G contains the binding site of eIF4E at the n-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product acts as a general repressor of translation by forming a translationally inactive complex. In vitro and in vivo studies have shown that translation of this mRNA is initiated only at non-aug (GUG) codons. Alternative splicing transcript variants encoding different isoforms of this gene have been described.