Analysis of ENSA Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0927-LGZ)

Introduction

Official Full Name: endosulfine alpha
Also known as: ARPP-19e
The protein encoded by this gene belongs to the highly conserved camp-regulated phosphorylation protein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, located on the plasma membrane of pancreatic β cells, and plays a key role in controlling the insulin release of pancreatic β cells. This protein is considered an endogenous regulator of KATP channels. In vitro studies have shown that this protein regulates insulin secretion through the interaction with the KATP channel, and this gene is considered as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encode distinct isoforms.