Analysis of EphB6/Eph Receptor B6 by ELISA (CAT#: STEM-MB-1582-LGZ)

Introduction

According to structure and sequence relationship, Ephrins can be divided into ephrin-A (EFNA) class and ephrin-B (EFNB) class. Ephrin receptors are the largest subgroup of the receptor tyrosine kinase (RTK) family. Ephrin type B receptor 6 (EphB6) is an unusual Eph receptor that lacks catalytic ability due to alterations in its kinase domain. EphB6 can positively and negatively regulate cell adhesion and migration. In addition, Ephrin-B2 may be a physiological ligand of EphB6 receptor. In several tumor types, including breast cancer, increased metastatic activity was associated with reduced expression of the EphB6 receptor, suggesting that EphB6 may act as a suppressor of cancer invasion. EphB6 suppresses cancer invasion through c-Cbl-dependent signaling, morphological changes, and cell attachment, suggesting that EphB6 may be a useful prognostic indicator and therapeutic target.