Analysis of ERG Gene Rearrangement by Southern Blot Technology (CAT#: STEM-MHT-0015-LGZ)

Introduction

Official Full Name: ETS transcription factor ERG<br />Also known as: p55; erg-3<br />This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcription factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (dot) domain involved in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelial layer, inducing vascular cell remodeling. It also regulates hematopoiesis, and the differentiation and maturation of megakaryocytes. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than 20 transcript variants have been reported to result from the combined use of three alternative promoters and multiple alternative splicing events, but the full-length nature of many of these variants has not been determined.