Analysis of Fas Ligand/TNFSF6 by ELISA (CAT#: STEM-MB-1532-LGZ)

Introduction

Fas ligand, also known as TNFSF6, FasL, or CD95L, is a member of the tumor necrosis factor (TNF) family. It is a homologous trimer type II transmembrane protein expressed on cytotoxic T lymphocytes. Extracellular matrix metalloproteinase MMP-7 cleaved membrane-bound FasL at conserved cleavage sites to produce soluble Fas ligands. Fas ligand/receptor interactions play an important role in regulating the immune system and cancer progression. It generates signals through trimerization of FASRs, which usually leads to apoptosis or death. Apoptosis induced by Fas-Fas ligand binding plays a critical role in the regulation of the immune system. Its functions include T cell homeostasis, cytotoxic T cell activity, immune privilege, maternal tolerance, and tumor counterattack. Defective Fas mediated apoptosis can lead to tumor development and drug resistance in existing tumors. Mutations in Fas genes are associated with an autoimmune lymphoproliferative syndrome (ALPS).