Analysis of Fas/TNFRSF6/CD95 by ELISA (CAT#: STEM-MB-1533-LGZ)

Introduction

Fas, also known as APO-1, CD95 or TNFRSF6, is a cell surface receptor that transduces apoptosis signals. It is one of two pathways of apoptosis, the other being the mitochondrial pathway. Once bound to the ligand, Fas forms a death-inducing signaling complex. Membrane-anchored Fas ligand trimers on adjacent cell surfaces lead to Fas oligomerization. Recent studies in mouse models have shown that Fas promotes tumor growth, but the Human Cancer Genomics database suggests that Fas acts as a tumor suppressor. In mouse models of colon cancer induced by AOM-DSS and sarcoma induced by MCA, Fas was shown to be a tumor suppressor. In addition, Fas can mediate the antitumor cytotoxicity of tumor-specific cytotoxic T cells. It has been reported that serum Fas levels are elevated in patients with cancer and autoimmune diseases, and the former may be derived from the tumor cells themselves.