Analysis of FBXO2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1309-LGZ)

Introduction

Official Full Name: F-box protein 2<br />Also known as: FBG1; FBX2; Fbs1; OCP1; NFB42<br />This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the ubiquitin-protein ligase complex SCFs (SKP1-cullin-F-box) and function in phosphorylation-dependent ubiquitination. F-box proteins were classified into 3 classes: Fbws containing the WD-40 domain, Fbws containing leucine-rich repeats, and Fbxs containing different protein interaction modules or without recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to rat NFB42 (neural F Box 42 kDa) protein, which is enriched in the nervous system and may play a role in maintaining the post-mitotic state of neurons.