Analysis of FBXW5 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2017-LGZ)

Introduction

Official Full Name: F-box and WD repeat domain containing 5<br />Also known as: Fbw5<br />This gene encodes a member of the F-box protein family, whose members are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the ubiquitin-protein ligase complex SCFs (SKP1-cullin-F-box) and function in phosphorylation-dependent ubiquitination. F-box proteins fall into three classes: Fbws containing the WD-40 domain, Fbws containing leucine-rich repeats, and Fbxs containing distinct protein interaction modules or no recognizable motifs. The protein encoded by the gene contains not only an F-box motif, but also a WD-40 domain, which belongs to the Fbw class. Alternative splicing transcript variants encoding different isoforms of this gene have been identified, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates and thus not represented.