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Official Full Name: F-box and WD repeat domain containing 5
Also known as: Fbw5
This gene encodes a member of the F-box protein family, whose members are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the ubiquitin-protein ligase complex SCFs (SKP1-cullin-F-box) and function in phosphorylation-dependent ubiquitination. F-box proteins fall into three classes: Fbws containing the WD-40 domain, Fbws containing leucine-rich repeats, and Fbxs containing distinct protein interaction modules or no recognizable motifs. The protein encoded by the gene contains not only an F-box motif, but also a WD-40 domain, which belongs to the Fbw class. Alternative splicing transcript variants encoding different isoforms of this gene have been identified, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates and thus not represented.