Analysis of FGF-19 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0173-LGZ)

Introduction

Fibroblast growth factor 19 (FGF-19) is encoded by the FGF-19 gene in humans. FGF-19 regulates bile acid synthesis and inhibits CYP7A1 through the FGFR4/Klotho-β receptor complex in the liver. In mouse models, FGF-19 also has metabolic effects, affecting glucose and lipid metabolism. Decreased FGF-19 in patients with chronic diarrhea due to bile acid malabsorption. FGF-19 is also present in the liver of cholestasis patients. FGF-19 expression is reduced in patients with metabolic syndrome, nonalcoholic fatty liver disease, and insulin resistance.