Analysis of FMOD Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0997-LGZ)

Introduction

Official Full Name: fibromodulin<br />Also known as: FM; SLRR2E<br />Fibromodulin belongs to the family of small interstitial proteoglycans. The central region of the encoded protein contains leucine-rich repeats with four keratin sulfate chains flanked by terminal domains containing disulfide bonds. The encoded protein may play a role in the assembly of the extracellular matrix due to interactions with type I and type II collagen fibrils and inhibition of fibrogenesis in vitro. It may also regulate TGF-β activity by sequestering TGF-β into the extracellular matrix. The sequence variation of this gene may be related to the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.