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Official Full Name: GEN1 Holliday junction 5' flap endonuclease
Also known as: Gen
This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in the breakdown of Holliday junctions, intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. This protein breaks down holiday junctions by forming a double nick at the junction, resulting in a gapped duplex product that can be ligated. Furthermore, this protein has been found to localize to the centrosome, where it is involved in the regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.