Analysis of GFAP (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0207-LGZ)

Introduction

Glial Fibrillary Acidic Protein (GFAP) is a marker of astrocyte activation. GFAP is a type III intermediate filament protein that exists as a monomer. GFAP is mainly distributed in the astrocytes of the central nervous system, participates in the formation of the cytoskeleton and maintains its tension strength. It is also expressed in chondrocytes, fibroblasts, myoepithelial cells, lymphocytes, and hepatic stellate cells. However, the GFAP expressed in the peripheral system cannot be detected by the GFAP monoclonal antibody in the central nervous system, suggesting that there may be structural differences between the two sources of GFAP. GFAP may be specific to the nervous system.