Analysis of GSTM4 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1194-LGZ)

Introduction

Official Full Name: glutathione S-transferase mu 4<br />Also known as: GTM4; GSTM4-4<br />The cytoplasmic and membrane-bound forms of glutathione S-transferase are encoded by two distinct epigene families. Currently, eight different classes of soluble mammalian cytoplasmic glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. This gene encodes glutathione s-transferase and belongs to the mu class. This class of enzymes detoxifies electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugating glutathione. Genes encoding mu-like enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can alter an individual's susceptibility to carcinogens and toxins, and can also affect the toxicity and efficacy of certain drugs. Diversification of these genes occurs in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate increasing numbers of foreign compounds. Multiple transcript variants have been identified, each encoding a different protein isoform.