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Heat shock protein 27(HSP-27) is a member of the low molecular weight heat shock protein family. Hsp27 is an important protein involved in drug resistance, cell growth, apoptosis, tumor occurrence and metastasis, etc. These functions mediated by Hsp27 may be related to its effects on other proteins. When the cells were not stressed, the expression of Hsp27 was low and mainly presented in large polymers, and Hsp27 under such polymers generally had no activity. When cells are stressed, Hsp27 expression is increased and phosphorylated, making Hsp27 active and performing some of its functions.