Analysis of IFI16 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1035-LGZ)

Introduction

Official Full Name: interferon gamma inducible protein 16<br />Also known as: PYHIN2; IFNGIP1<br />This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigen with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleolus and interacts with p53 and retinoblastoma-1. It regulates p53 function and inhibits cell growth through Ras/Raf signaling pathway. Alternative splice transcript variants of this gene have been found to encode distinct isoforms.