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Insulin-like growth factor 2 receptor (IGF2R), also known as cation-independent mannose-6-phosphate receptor (CI-MPR), is a protein encoded by the IGF2R gene. It is a multifunctional protein receptor. The function of IGF2R is to clear IGF2 from the cell surface to attenuate signaling and to transport lysosomal acid hydrolase precursors from the Golgi apparatus to lysosomes.