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The protein encoded by the IL-8 (HA) gene is a member of the CXC chemokine family. This chemokine is one of the main mediators of the inflammatory response. This chemokine is secreted by several types of cells. It acts as a chemoattractant and is a potent angiogenic factor. The gene is thought to play a role in the pathogenesis of bronchiolitis, a common respiratory disease caused by viral infection. This gene and 10 other members of the CXC chemokine gene family form a chemokine gene cluster in a region that maps to chromosome 4q.