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As a new biomarker, ST2 has been widely used in recent years and is one of the main directions of future development. ST2, a protein biomarker of cardiac stress encoded by the IL1RL1 gene, is a member of the interleukin-1 receptor family, expressed as transmembrane (ST2L) and soluble isotype (sST2) subtypes. sST2 has been shown to be physiologically associated with cardiac hypertrophy, fibrosis, and ventricular dysfunction.