Analysis of IPO7 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2262-LGZ)

Introduction

Official Full Name: importin 7<br />Also known as: Imp7; RANBP7<br />The importin-α/β complex and GTPase Ran mediate nuclear import of proteins through canonical nuclear localization signals. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif associated with the Ran binding site of importin-β. Similar to importin-beta, this protein prevents RanGAP1 from activating Ran's GTPase, inhibits nucleotide exchange on RanGTP, and directly binds to the nuclear pore complex, competing with importin-beta and transport proteins for binding sites. The protein has a Ran-dependent translocation cycle that rapidly crosses the nuclear membrane in both directions. At least four importin β-like transport receptors directly bind and import ribosomal proteins, namely importin β itself, transporter, RanBP5 and RanBP7.