Analysis of Klotho (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0380-LGZ)

Introduction

Klotho is a transmembrane protein that regulates the sensitivity of organisms to insulin. It has β-glucuronidase activity and can hydrolyze β-glucuronic acid, which is related to human aging. Circulating klotox in plasma decreases gradually with age. β-Klotsole will cooperate with FGF receptors, and can bind to FGF19, FGF20, FGF23 and other fibroblast growth factors (FGF). The mechanism of action of Kloxol is still unknown, but it is known that it can regulate the calcium balance of cells by increasing the expression of TRPV5 and reducing the expression of TRPC6. In addition, Kloxol also increases the expression of inward rectifier ion channel ROMK.