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Official Full Name: left-right determination factor 1<br />Also known as: LEFTB; LEFTYB<br />This gene encodes a secreted ligand for TGF-beta (transforming growth factor-beta) superfamily proteins. Ligands of this family bind various TGF-β receptors, leading to the recruitment and activation of SMAD family transcription factors, which regulate gene expression. The encoded preproprotein undergoes proteolytic processing to generate the mature protein, which plays a role in determining the asymmetry of left and right organ systems during development. This gene is closely related to related family members and related pseudogenes.