Analysis of M-CSF (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0407-LGZ)

Introduction

M-CSF (macrophage colony-stimulating factor, CSF-1) is an essential survival factor for the proliferation and development of monocyte, macrophage and osteoclast progenitor cells. M-CSF also induces macrophages to secrete VEGF (vascular endothelial growth factor), thereby mediating the mobilization and neovascularization of endothelial progenitor cells. M-CSF exists in several biologically active isoforms of varying potency and stability. The full-length protein is synthesized as a transmembrane protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle.