Analysis of MCP-1 (Human) by ELISA (CAT#: STEM-MB-1033-LGZ)

Introduction

Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. This protein is mainly induced by the platelet-derived growth factor (PDGF) gene. The biological effects of MCP-1 are mediated through the specific G protein-coupled receptor CCR2, which in turn activates signal transduction pathways leading to monocyte trafficking. The migration of monocytes from the blood to the vascular endothelium is required for routine immune surveillance of the tissue as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial cells, epithelial cells, smooth muscle cells, mesangial cells, astrocytes, monocytes, and microglia. MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced le during neuroinflammites.