Analysis of MCP-5/CCL12 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0406-LGZ)

Introduction

CCL12, also known as monocyte chemoattractant protein 5 (MCP-5), belongs to the CC chemokine cluster on mouse chromosome 11. Because it is structurally closest to human MCP-1 (66% amino acid identity), it is sometimes referred to as an MCP-1-related chemokine. CCL12 is a potent chemoattractant for peripheral blood monocytes, a chemokine that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Induces calcium flux in peripheral blood mononuclear cells but not in purified mouse eosinophils or neutrophils. CCL12 is a potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and host response to pathogens, and may play a key role in the early stages of allergic lung inflammation.