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Official Full Name: mitochondrial ribosomal protein S21
Also known as: MDS016; RPMS21; MRP-S21
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist in protein synthesis within mitochondria. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They are estimated to be composed of 75% protein and rRNA compared to prokaryotic ribosomes, whose proportions are reversed. Another difference between mammalian ribosomes and prokaryotic ribosomes is that the latter contain 5S rRNA. The proteins that make up the mitochondrial body vary widely in sequence and sometimes in biochemical properties across species, making sequence homology difficult to identify. The gene encodes a 28S subunit protein, which belongs to the S21P family of ribosomal proteins. Pseudogenes corresponding to this gene are located on chromosomes 1p, 1q, 9p, 10p, 10q, 16q and 17q. Analysis of available sequence data identified distinct splice variants in the 5' UTR; both transcripts encode the same protein.