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Official Full Name: myosin heavy chain 11<br />Also known as: AAT4; FAA4; SMHC; SMMHC; VSCM2; SMMS-1<br />The protein encoded by this gene is smooth muscle myosin, which belongs to the myosin heavy chain family. The gene product is a subunit of a hexameric protein consisting of two heavy chain subunits and two pairs of non-identical light chain subunits. It is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Chromosomal rearrangements involving this gene have been associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4.